Ontology highlight
ABSTRACT:
SUBMITTER: Owusu-Ansah A
PROVIDER: S-EPMC4684475 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Owusu-Ansah Amma A Ihunnah Chibueze A CA Walker Aisha L AL Ofori-Acquah Solomon F SF
Translational research : the journal of laboratory and clinical medicine 20150711 1
Sickle cell disease (SCD) is a monogenic globin disorder characterized by the production of a structurally abnormal hemoglobin (Hb) variant Hb S, which causes severe hemolytic anemia, episodic painful vaso-occlusion, and ultimately end-organ damage. The primary disease pathophysiology is intracellular Hb S polymerization and consequent sickling of erythrocytes. It has become evident for more than several decades that a more complex disease process contributes to the myriad of clinical complicati ...[more]