Ontology highlight
ABSTRACT:
SUBMITTER: Abraham A
PROVIDER: S-EPMC5067194 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Abraham Allistair A Jacobsohn David A DA Bollard Catherine M CM
Cytotherapy 20160714 11
Sickle cell disease (SCD) is a monogenic red cell disorder affecting more than 300 000 annual births worldwide and leading to significant organ toxicity and premature mortality. Although chronic therapies such as hydroxyurea have improved outcomes, more durable therapeutic and curative options are still being investigated. Newer understanding of the disease has implicated invariant natural killer T cells as a critical immune profile that potentiates SCD. Hence, targeting this cell population may ...[more]