Ontology highlight
ABSTRACT:
SUBMITTER: Tan Y
PROVIDER: S-EPMC4685471 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Tan Yunhao Y Zanoni Ivan I Cullen Thomas W TW Goodman Andrew L AL Kagan Jonathan C JC
Immunity 20151103 5
Microbe-induced receptor trafficking has emerged as an essential means to promote innate immune signal transduction. Upon detection of bacterial lipopolysaccharides (LPS), CD14 induces an inflammatory endocytosis pathway that delivers Toll-like receptor 4 (TLR4) to endosomes. Although several regulators of CD14-dependent TLR4 endocytosis have been identified, the cargo-selection mechanism during this process remains unknown. We reveal that, in contrast to classic cytosolic interactions that prom ...[more]