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Switchable Release of Entrapped Nanoparticles from Alginate Hydrogels.

ABSTRACT: Natural biological processes are intricately controlled by the timing and spatial distribution of various cues. To mimic this precise level of control, the physical sizes of gold nanoparticles are utilized to sterically entrap them in hydrogel materials, where they are subsequently released only in response to ultrasound. These nanoparticles can transport bioactive factors to cells and direct cell behavior on-demand.

SUBMITTER: Kearney CJ

PROVIDER: S-EPMC4685946 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Switchable Release of Entrapped Nanoparticles from Alginate Hydrogels.

Kearney Cathal J CJ Skaat Hadas H Kennedy Stephen M SM Hu Jennifer J Darnell Max M Raimondo Theresa M TM Mooney David J DJ

Advanced healthcare materials 20150605 11

Natural biological processes are intricately controlled by the timing and spatial distribution of various cues. To mimic this precise level of control, the physical sizes of gold nanoparticles are utilized to sterically entrap them in hydrogel materials, where they are subsequently released only in response to ultrasound. These nanoparticles can transport bioactive factors to cells and direct cell behavior on-demand. ...[more]

PMID: 26044285

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