Ontology highlight
ABSTRACT:
SUBMITTER: Di Paolo NC
PROVIDER: S-EPMC4685953 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Immunity 20151201 6
The interleukin-1 receptor I (IL-1RI) is critical for host resistance to Mycobacterium tuberculosis (Mtb), yet the mechanisms of IL-1RI-mediated pathogen control remain unclear. Here, we show that without IL-1RI, Mtb-infected newly recruited Ly6G(hi) myeloid cells failed to upregulate tumor necrosis factor receptor I (TNF-RI) and to produce reactive oxygen species, resulting in compromised pathogen control. Furthermore, simultaneous ablation of IL-1RI and TNF-RI signaling on either stroma or hem ...[more]