Ontology highlight
ABSTRACT:
SUBMITTER: Olleros ML
PROVIDER: S-EPMC4534677 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Olleros Maria L ML Chavez-Galan Leslie L Segueni Noria N Bourigault Marie L ML Vesin Dominique D Kruglov Andrey A AA Drutskaya Marina S MS Bisig Ruth R Ehlers Stefan S Aly Sahar S Walter Kerstin K Kuprash Dmitry V DV Chouchkova Miliana M Kozlov Sergei V SV Erard François F Ryffel Bernard B Quesniaux Valérie F J VF Nedospasov Sergei A SA Garcia Irene I
Infection and immunity 20150629 9
Tumor necrosis factor (TNF) is an important cytokine for host defense against pathogens but is also associated with the development of human immunopathologies. TNF blockade effectively ameliorates many chronic inflammatory conditions but compromises host immunity to tuberculosis. The search for novel, more specific human TNF blockers requires the development of a reliable animal model. We used a novel mouse model with complete replacement of the mouse TNF gene by its human ortholog (human TNF [h ...[more]