Ontology highlight
ABSTRACT:
SUBMITTER: Atherton P
PROVIDER: S-EPMC4686655 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Atherton Paul P Stutchbury Ben B Wang De-Yao DY Jethwa Devina D Tsang Ricky R Meiler-Rodriguez Eugenia E Wang Pengbo P Bate Neil N Zent Roy R Barsukov Igor L IL Goult Benjamin T BT Critchley David R DR Ballestrem Christoph C
Nature communications 20151204
The link between extracellular-matrix-bound integrins and intracellular F-actin is essential for cell spreading and migration. Here, we demonstrate how the actin-binding proteins talin and vinculin cooperate to provide this link. By expressing structure-based talin mutants in talin null cells, we show that while the C-terminal actin-binding site (ABS3) in talin is required for adhesion complex assembly, the central ABS2 is essential for focal adhesion (FA) maturation. Thus, although ABS2 mutants ...[more]