Ontology highlight
ABSTRACT:
SUBMITTER: Tran DT
PROVIDER: S-EPMC4686765 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Tran Duy T DT Masedunskas Andrius A Weigert Roberto R Ten Hagen Kelly G KG
Nature communications 20151207
The actin cytoskeleton plays crucial roles in many cellular processes, including regulated secretion. However, the mechanisms controlling F-actin dynamics in this process are largely unknown. Through 3D time-lapse imaging in a secreting organ, we show that F-actin is actively disassembled along the apical plasma membrane at the site of secretory vesicle fusion and re-assembled directionally on vesicle membranes. Moreover, we show that fusion pore formation and PIP2 redistribution precedes actin ...[more]