Ontology highlight
ABSTRACT:
SUBMITTER: Jadhav B
PROVIDER: S-EPMC4686813 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Jadhav Bhalchandra B McKenna Michael M Johnson Nicholas N High Stephen S Sinning Irmgard I Pool Martin R MR
Nature communications 20151204
Two distinct pathways deliver secretory proteins to the Sec61 protein translocase in the endoplasmic reticulum membrane. The canonical pathway requires the signal recognition particle (SRP) and its cognate receptor (SR), and targets ribosome-associated proteins to the Sec translocase. The SRP-independent pathway requires the Sec translocase-associated ER membrane protein Sec62 and can be uncoupled from translation. Here we show that SR switches translocons to SRP-dependent translocation by displ ...[more]