Ontology highlight
ABSTRACT:
SUBMITTER: Conti BJ
PROVIDER: S-EPMC4402133 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Conti Brian J BJ Devaraneni Prasanna K PK Yang Zhongying Z David Larry L LL Skach William R WR
Molecular cell 20150319 2
The ER Sec61 translocon is a large macromolecular machine responsible for partitioning secretory and membrane polypeptides into the lumen, cytosol, and lipid bilayer. Because the Sec61 protein-conducting channel has been isolated in multiple membrane-derived complexes, we determined how the nascent polypeptide modulates translocon component associations during defined cotranslational translocation events. The model substrate preprolactin (pPL) was isolated principally with Sec61αβγ upon membrane ...[more]