Bispecific antibodies and their applications.
Ontology highlight
ABSTRACT:
SUBMITTER: Fan G
PROVIDER: S-EPMC4687327 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
Bispecific antibodies and their applications.
Fan Gaowei G Wang Zujian Z Hao Mingju M Li Jinming J
Journal of hematology & oncology 20151221
Bispecific antibodies (BsAbs) recognize two different epitopes. This dual specificity opens up a wide range of applications, including redirecting T cells to tumor cells, blocking two different signaling pathways simultaneously, dual targeting of different disease mediators, and delivering payloads to targeted sites. The approval of catumaxomab (anti-EpCAM and anti-CD3) and blinatumomab (anti-CD19 and anti-CD3) has become a major milestone in the development of bsAbs. Currently, more than 60 dif ...[more]
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