Ontology highlight
ABSTRACT:
SUBMITTER: Huber CM
PROVIDER: S-EPMC4687420 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Hüber Christian M CM Doisne Jean-Marc JM Colucci Francesco F
European journal of immunology 20150417 6
Mismatched hematopoietic cell transplants for treating leukemia are complicated by graft versus host disease (GvHD). Here, we show that adoptively transferred IL-12/15/18-preactivated NK cells suppress GvHD in a mouse model of fully mismatched hematopoietic cell transplantation. These IL-12/15/18-preactivated NK cells maintained Eomesodermin (Eomes) and T-bet expression upon transfer and, while there was no evidence of direct killing of donor T cells or host DCs by the IL-12/15/18-preactivated N ...[more]