Ontology highlight
ABSTRACT:
SUBMITTER: Shah NN
PROVIDER: S-EPMC4311226 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Shah Nirali N NN Baird Kristin K Delbrook Cynthia P CP Fleisher Thomas A TA Kohler Mark E ME Rampertaap Shakuntala S Lemberg Kimberly K Hurley Carolyn K CK Kleiner David E DE Merchant Melinda S MS Pittaluga Stefania S Sabatino Marianna M Stroncek David F DF Wayne Alan S AS Zhang Hua H Fry Terry J TJ Mackall Crystal L CL
Blood 20141201 5
Natural killer (NK) cells can enhance engraftment and mediate graft-versus-leukemia following allogeneic hematopoietic stem cell transplantation (HSCT), but the potency of graft-versus-leukemia mediated by naturally reconstituting NK cells following HSCT is limited. Preclinical studies demonstrate that activation of NK cells using interleukin-15 (IL-15) plus 4-1BBL upregulates activating receptor expression and augments killing capacity. In an effort to amplify the beneficial effects of NK cells ...[more]