Ontology highlight
ABSTRACT:
SUBMITTER: Geller R
PROVIDER: S-EPMC4687473 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Geller Ron R Domingo-Calap Pilar P Cuevas José M JM Rossolillo Paola P Negroni Matteo M Sanjuán Rafael R
Nature communications 20151009
In RNA viruses, mutations occur fast and have large fitness effects. While this affords remarkable adaptability, it can also endanger viral survival due to the accumulation of deleterious mutations. How RNA viruses reconcile these two opposed facets of mutation is still unknown. Here we show that, in human immunodeficiency virus (HIV-1), spontaneous mutations are not randomly located along the viral genome. We find that the viral mutation rate experiences a threefold reduction in the region enco ...[more]