Ontology highlight
ABSTRACT:
SUBMITTER: Zhou L
PROVIDER: S-EPMC4687583 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Zhou Liang L Yang Dong D Wang De-Juan DJ Xie Ya-Jun YJ Zhou Jia-Huan JH Zhou Lin L Huang Hao H Han Shuo S Shao Chong-Yu CY Li Hua-Shun HS Zhu J Julius JJ Qiu Meng-Sheng MS De Zeeuw Chris I CI Shen Ying Y
Proceedings of the National Academy of Sciences of the United States of America 20151130 50
Protein Numb, first identified as a cell-fate determinant in Drosophila, has been shown to promote the development of neurites in mammals and to be cotransported with endocytic receptors in clathrin-coated vesicles in vitro. Nevertheless, its function in mature neurons has not yet been elucidated. Here we show that cerebellar Purkinje cells (PCs) express high levels of Numb during adulthood and that conditional deletion of Numb in PCs is sufficient to impair motor coordination despite maintenanc ...[more]