Ontology highlight
ABSTRACT:
SUBMITTER: Wulff P
PROVIDER: S-EPMC2718327 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Wulff Peer P Schonewille Martijn M Renzi Massimiliano M Viltono Laura L Sassoè-Pognetto Marco M Badura Aleksandra A Gao Zhenyu Z Hoebeek Freek E FE van Dorp Stijn S Wisden William W Farrant Mark M De Zeeuw Chris I CI
Nature neuroscience 20090705 8
Although feedforward inhibition onto Purkinje cells was first documented 40 years ago, we understand little of how inhibitory interneurons contribute to cerebellar function in behaving animals. Using a mouse line (PC-Deltagamma2) in which GABA(A) receptor-mediated synaptic inhibition is selectively removed from Purkinje cells, we examined how feedforward inhibition from molecular layer interneurons regulates adaptation of the vestibulo-ocular reflex. Although impairment of baseline motor perform ...[more]