Ontology highlight
ABSTRACT:
SUBMITTER: Molla-Herman A
PROVIDER: S-EPMC4687792 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Molla-Herman Anahi A Vallés Ana Maria AM Ganem-Elbaz Carine C Antoniewski Christophe C Huynh Jean-René JR
The EMBO journal 20151015 24
RNase P is a conserved endonuclease that processes the 5' trailer of tRNA precursors. We have isolated mutations in Rpp30, a subunit of RNase P, and find that these induce complete sterility in Drosophila females. Here, we show that sterility is not due to a shortage of mature tRNAs, but that atrophied ovaries result from the activation of several DNA damage checkpoint proteins, including p53, Claspin, and Chk2. Indeed, we find that tRNA processing defects lead to increased replication stress an ...[more]