Ontology highlight
ABSTRACT:
SUBMITTER: Garg S
PROVIDER: S-EPMC4688409 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Garg Swati S Sharma Vijeta V Ramu Dandugudumula D Singh Shailja S
Systems and synthetic biology 20150408 Suppl 1
Plasmodium falciparum perforin like proteins (PfPLPs) are an important arsenal for the entry and exit of malaria parasites. These proteins bind and oligomerize on the membrane in calcium dependent manner and form an open pore. The calcium dependent pore forming activity of PLPs is usually conferred by their C2 like C-terminal domain. Here, we have tried to elucidate the calcium binding residues in the C-terminal domain of PfPLP1, a member of P. falciparum PLPs, playing a crucial role in calcium ...[more]