Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesis.
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ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC4689155 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesis.
Xu Xuehe X Watt David S DS Liu Chunming C
Acta biochimica et biophysica Sinica 20150914 1
Thymine DNA glycosylase (TDG) is a multifunctional protein that plays important roles in DNA repair, DNA demethylation, and transcriptional regulation. These diverse functions make TDG a unique enzyme in embryonic development and carcinogenesis. This review discusses the molecular function of TDG in human cancers and the previously unrecognized value of TDG as a potential target for drug therapy. ...[more]
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