Ontology highlight
ABSTRACT:
SUBMITTER: Sato PY
PROVIDER: S-EPMC4689631 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Sato Priscila Y PY Chuprun J Kurt JK Ibetti Jessica J Cannavo Alessandro A Drosatos Konstantinos K Elrod John W JW Koch Walter J WJ
Journal of molecular and cellular cardiology 20151023 Pt B
The G protein-coupled receptor kinase-2 (GRK2) is upregulated in the injured heart and contributes to heart failure pathogenesis. GRK2 was recently shown to associate with mitochondria but its functional impact in myocytes due to this localization is unclear. This study was undertaken to determine the effect of elevated GRK2 on mitochondrial respiration in cardiomyocytes. Sub-fractionation of purified cardiac mitochondria revealed that basally GRK2 is found in multiple compartments. Overexpressi ...[more]