Ontology highlight
ABSTRACT:
SUBMITTER: Helbo AS
PROVIDER: S-EPMC4690025 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Helbo Alexandra Søgaard AS Treppendahl Marianne M Aslan Derya D Dimopoulos Konstantinos K Nandrup-Bus Cecilie C Holm Mette Skov MS Andersen Mette Klarskov MK Liang Gangning G Kristensen Lasse Sommer LS Grønbæk Kirsten K
Genes 20151014 4
Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematopoietic disorders. MDS is frequently associated with deletions on chromosome 5q as well as aberrant DNA methylation patterns including hypermethylation of key tumor suppressors. We have previously shown that hypermethylation and silencing of the non-coding RNA VTRNA2-1 are correlated with poor outcomes in acute myeloid leukemia patients. In this study, we find that VTRNA1-2 and VTRNA1-3, both located on chromosome 5q, can be ...[more]