Super Enhancers in Cancers, Complex Disease, and Developmental Disorders.
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ABSTRACT:
SUBMITTER: Niederriter AR
PROVIDER: S-EPMC4690034 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
Super Enhancers in Cancers, Complex Disease, and Developmental Disorders.
Niederriter Adrienne R AR Varshney Arushi A Parker Stephen C J SC Martin Donna M DM
Genes 20151109 4
Recently, unique areas of transcriptional regulation termed super-enhancers have been identified and implicated in human disease. Defined by their magnitude of size, transcription factor density, and binding of transcriptional machinery, super-enhancers have been associated with genes driving cell differentiation. While their functions are not completely understood, it is clear that these regions driving high-level transcription are susceptible to perturbation, and trait-associated single nucleo ...[more]
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