Ontology highlight
ABSTRACT:
SUBMITTER: Jiang JH
PROVIDER: S-EPMC4690039 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Jiang Jhih-Hang JH Peleg Anton Y AY
Genes 20151130 4
Reduced susceptibility to daptomycin in Staphylococcus aureus has now been described, leading to clinical failures. Here we determined the impact of daptomycin and gentamicin combination therapy on bactericidal activity and resistance emergence using daptomycin-susceptible and -resistant isolates with mutations linked to previous daptomycin or vancomycin exposure. Enhanced killing of S. aureus was observed when gentamicin was combined with daptomycin, most commonly with daptomycin concentrations ...[more]