Dataset Information
An Umpolung Strategy for the Synthesis of ?-Aminoketones via Copper-Catalyzed Electrophilic Amination of Cyclopropanols.
Ontology highlight
ABSTRACT:
SUBMITTER: Ye Z
PROVIDER: S-EPMC4690534 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
An Umpolung Strategy for the Synthesis of β-Aminoketones via Copper-Catalyzed Electrophilic Amination of Cyclopropanols.
Organic letters 20150417 9
A novel copper-catalyzed electrophilic amination of cyclopropanols with O-benzoyl-N,N-dialkylhydroxylamines to synthesize various β-aminoketones via a sequence that includes C-C bond cleavage and Csp(3)-N bond formation is reported. The reaction conditions are mild and tolerate a wide range of functional groups including benzoate, tosylate, expoxide, and α,β-unsaturated carbonyls, which are incompatible in the traditional amine nucleophilic conjugate addition and the Mannich reaction conditions. ...[more]