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Copper-catalyzed electrophilic amination of heteroarenes and arenes by C-H zincation.

ABSTRACT: Direct amination of heteroarenes and arenes has been achieved in a one-pot C?H zincation/copper-catalyzed electrophilic amination procedure. This amination method provides an efficient and rapid approach to access a diverse range of heteroaromatic and aromatic amines including those previously inaccessible using C?H amination methods. The mild reaction conditions and good functional-group compatibility demonstrate its great potential for the synthesis of important and complex amines.

SUBMITTER: McDonald SL

PROVIDER: S-EPMC4668583 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Copper-catalyzed electrophilic amination of heteroarenes and arenes by C-H zincation.

McDonald Stacey L SL Hendrick Charles E CE Wang Qiu Q

Angewandte Chemie (International ed. in English) 20140325 18

Direct amination of heteroarenes and arenes has been achieved in a one-pot CH zincation/copper-catalyzed electrophilic amination procedure. This amination method provides an efficient and rapid approach to access a diverse range of heteroaromatic and aromatic amines including those previously inaccessible using CH amination methods. The mild reaction conditions and good functional-group compatibility demonstrate its great potential for the synthesis of important and complex amines. ...[more]

PMID: 24668522

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