Ontology highlight
ABSTRACT:
SUBMITTER: Caster DJ
PROVIDER: S-EPMC4690797 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Caster Dawn J DJ Korte Erik A EA Merchant Michael L ML Klein Jon B JB Wilkey Daniel W DW Rovin Brad H BH Birmingham Dan J DJ Harley John B JB Cobb Beth L BL Namjou Bahram B McLeish Kenneth R KR Powell David W DW
Proteomics. Clinical applications 20150612 11-12
<h4>Purpose</h4>Patients with systemic lupus erythematosus (SLE) frequently develop lupus nephritis (LN), a complication frequently leading to end stage kidney disease. Immune complex deposition in the glomerulus is central to the development of LN. Using a targeted proteomic approach, we tested the hypothesis that autoantibodies targeting glomerular antigens contribute to the development of LN.<h4>Experimental design</h4>Human podocyte and glomerular proteins were separated by SDS-PAGE and immu ...[more]