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Non-Coding RNAs in Multiple Myeloma Bone Disease Pathophysiology.

ABSTRACT: Bone remodeling is uncoupled in the multiple myeloma (MM) bone marrow niche, resulting in enhanced osteoclastogenesis responsible of MM-related bone disease (MMBD). Several studies have disclosed the mechanisms underlying increased osteoclast formation and activity triggered by the various cellular components of the MM bone marrow microenvironment, leading to the identification of novel targets for therapeutic intervention. In this regard, recent attention has been given to non-coding RNA (ncRNA) molecules, that finely tune gene expression programs involved in bone homeostasis both in physiological and pathological settings. In this review, we will analyze major signaling pathways involved in MMBD pathophysiology, and report emerging evidence of their regulation by different classes of ncRNAs.

SUBMITTER: Raimondi L

PROVIDER: S-EPMC7549375 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Non-Coding RNAs in Multiple Myeloma Bone Disease Pathophysiology.

Raimondi Lavinia L De Luca Angela A Giavaresi Gianluca G Raimondo Stefania S Gallo Alessia A Taiana Elisa E Alessandro Riccardo R Rossi Marco M Neri Antonino A Viglietto Giuseppe G Amodio Nicola N

Non-coding RNA 20200909 3

Bone remodeling is uncoupled in the multiple myeloma (MM) bone marrow niche, resulting in enhanced osteoclastogenesis responsible of MM-related bone disease (MMBD). Several studies have disclosed the mechanisms underlying increased osteoclast formation and activity triggered by the various cellular components of the MM bone marrow microenvironment, leading to the identification of novel targets for therapeutic intervention. In this regard, recent attention has been given to non-coding RNA (ncRNA ...[more]

PMID: 32916806

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