Ontology highlight
ABSTRACT:
SUBMITTER: Richmond CA
PROVIDER: S-EPMC4691543 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Cell reports 20151210 11
The cellular and molecular mechanisms underlying adaptive changes to physiological stress within the intestinal epithelium remain poorly understood. Here, we show that PTEN, a negative regulator of the PI3K→AKT→mTORC1-signaling pathway, is an important regulator of dormant intestinal stem cells (d-ISCs). Acute nutrient deprivation leads to transient PTEN phosphorylation within d-ISCs and a corresponding increase in their number. This release of PTEN inhibition renders d-ISCs functionally poised ...[more]