Ontology highlight
ABSTRACT:
SUBMITTER: Rajakumara E
PROVIDER: S-EPMC4691841 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20110701 2
Histone methylation occurs on both lysine and arginine residues, and its dynamic regulation plays a critical role in chromatin biology. Here we identify the UHRF1 PHD finger (PHD(UHRF1)), an important regulator of DNA CpG methylation, as a histone H3 unmodified arginine 2 (H3R2) recognition modality. This conclusion is based on binding studies and cocrystal structures of PHD(UHRF1) bound to histone H3 peptides, where the guanidinium group of unmodified R2 forms an extensive intermolecular hydrog ...[more]