Ontology highlight
ABSTRACT:
SUBMITTER: Qiu Y
PROVIDER: S-EPMC3387664 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Qiu Yu Y Liu Lei L Zhao Chen C Han Chuanchun C Li Fudong F Zhang Jiahai J Wang Yan Y Li Guohong G Mei Yide Y Wu Mian M Wu Jihui J Shi Yunyu Y
Genes & development 20120601 12
Histone acetylation is a hallmark for gene transcription. As a histone acetyltransferase, MOZ (monocytic leukemia zinc finger protein) is important for HOX gene expression as well as embryo and postnatal development. In vivo, MOZ forms a tetrameric complex with other subunits, including several chromatin-binding modules with regulatory functions. Here we report the solution structure of the tandem PHD (plant homeodomain) finger (PHD12) of human MOZ in a free state and the 1.47 Å crystal structur ...[more]