Ontology highlight
ABSTRACT:
SUBMITTER: Zhou M
PROVIDER: S-EPMC4691890 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Zhou Mengying M Li Yini Y Hu Qi Q Bai Xiao-Chen XC Huang Weiyun W Yan Chuangye C Scheres Sjors H W SH Shi Yigong Y
Genes & development 20151105 22
The apoptotic protease-activating factor 1 (Apaf-1) controls the onset of many known forms of intrinsic apoptosis in mammals. Apaf-1 exists in normal cells as an autoinhibited monomer. Upon binding to cytochrome c and dATP, Apaf-1 oligomerizes into a heptameric complex known as the apoptosome, which recruits and activates cell-killing caspases. Here we present an atomic structure of an intact mammalian apoptosome at 3.8 Å resolution, determined by single-particle, cryo-electron microscopy (cryo- ...[more]