Ontology highlight
ABSTRACT:
SUBMITTER: Hu Q
PROVIDER: S-EPMC4246342 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Hu Qi Q Wu Di D Chen Wen W Yan Zhen Z Yan Chuangye C He Tianxi T Liang Qionglin Q Shi Yigong Y
Proceedings of the National Academy of Sciences of the United States of America 20141013 46
Autocatalytic activation of an initiator caspase triggers the onset of apoptosis. In dying cells, caspase-9 activation is mediated by a multimeric adaptor complex known as the Apaf-1 apoptosome. The molecular mechanism by which caspase-9 is activated by the Apaf-1 apoptosome remains largely unknown. Here we demonstrate that the previously reported 1:1 interaction between Apaf-1 caspase recruitment domain (CARD) and caspase-9 CARD is insufficient for the activation of caspase-9. Rather, formation ...[more]