Ontology highlight
ABSTRACT:
SUBMITTER: Yuan YR
PROVIDER: S-EPMC4692372 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20061001 10
Argonaute proteins are key components of the RNA-induced silencing complex (RISC). They provide both architectural and catalytic functionalities associated with small interfering RNA (siRNA) guide strand recognition and subsequent guide strand-mediated cleavage of complementary mRNAs. We report on the 3.0 A crystal structures of 22-mer and 26-mer siRNAs bound to Aquifex aeolicus Argonaute (Aa-Ago), where one 2 nt 3' overhang of the siRNA inserts into a cavity positioned on the outer surface of t ...[more]