Ontology highlight
ABSTRACT:
SUBMITTER: Pengo V
PROVIDER: S-EPMC4692529 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Pengo Vittorio V Zambon Carlo-Federico CF Fogar Paola P Padoan Andrea A Nante Giovanni G Pelloso Michela M Moz Stefania S Frigo Anna Chiara AC Groppa Francesca F Bozzato Dania D Tiso Enrico E Gnatta Elisa E Denas Gentian G Padayattil Jose Seena S Padrini Roberto R Basso Daniela D Plebani Mario M
PloS one 20151228 12
<h4>Unlabelled</h4>Genotype-guided warfarin dosing have been proposed to improve patient’s management. This study is aimed to determine whether a CYP2C9- VKORC1- CYP4F2-based pharmacogenetic algorithm is superior to a standard, clinically adopted, pharmacodynamic method. Two-hundred naïve patients with non-valvular atrial fibrillation were randomized to trial arms and 180 completed the study. No significant differences were found in the number of out-of-range INRs (INR<2.0 or >3.0) (p = 0.79) an ...[more]