DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer.
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ABSTRACT:
SUBMITTER: Velic D
PROVIDER: S-EPMC4693276 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
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DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer.
Velic Denis D Couturier Anthony M AM Ferreira Maria Tedim MT Rodrigue Amélie A Poirier Guy G GG Fleury Fabrice F Masson Jean-Yves JY
Biomolecules 20151120 4
For decades, radiotherapy and chemotherapy were the two only approaches exploiting DNA repair processes to fight against cancer. Nowadays, cancer therapeutics can be a major challenge when it comes to seeking personalized targeted medicine that is both effective and selective to the malignancy. Over the last decade, the discovery of new targeted therapies against DNA damage signalling and repair has offered the possibility of therapeutic improvements in oncology. In this review, we summarize the ...[more]
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