Ontology highlight
ABSTRACT:
SUBMITTER: Guseman AJ
PROVIDER: S-EPMC6514620 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Guseman Alex J AJ Gronenborn Angela M AM
The Journal of biological chemistry 20190501 19
Crystallin proteins, the dominant constituents of the eye lens, are prototypes of long-lived proteins. Such proteins can accumulate harmful modifications over their life span that render them prone to aggregation, which, in the case of lens crystallin, contributes to cataract formation. Lyon <i>et al.</i> now explore the structural and functional consequences of amino acid isomerization in α-crystallins using mass spectrometry, molecular dynamics simulations, and other strategies. Their results ...[more]