Ontology highlight
ABSTRACT:
SUBMITTER: Sanghvi VR
PROVIDER: S-EPMC4693296 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Sanghvi Viraj R VR Mavrakis Konstantinos J KJ Van der Meulen Joni J Boice Michael M Wolfe Andrew L AL Carty Mark M Mohan Prathibha P Rondou Pieter P Socci Nicholas D ND Benoit Yves Y Taghon Tom T Van Vlierberghe Pieter P Leslie Christina S CS Speleman Frank F Wendel Hans-Guido HG
Science signaling 20141118 352
The posttranscriptional control of gene expression by microRNAs (miRNAs) is highly redundant, and compensatory effects limit the consequences of the inactivation of individual miRNAs. This implies that only a few miRNAs can function as effective tumor suppressors. It is also the basis of our strategy to define functionally relevant miRNA target genes that are not under redundant control by other miRNAs. We identified a functionally interconnected group of miRNAs that exhibited a reduced abundanc ...[more]