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Automatic reactor for solid-phase synthesis of molecularly imprinted polymeric nanoparticles (MIP NPs) in water.

ABSTRACT: We report the development of an automated chemical reactor for solid-phase synthesis of MIP NPs in water. Operational parameters are under computer control, requiring minimal operator intervention. In this study, "ready for use" MIP NPs with sub-nanomolar affinity are prepared against pepsin A, trypsin and ?-amylase in only 4 hours.

SUBMITTER: Poma A

PROVIDER: S-EPMC4693954 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Automatic reactor for solid-phase synthesis of molecularly imprinted polymeric nanoparticles (MIP NPs) in water.

Poma Alessandro A Guerreiro Antonio A Caygill Sarah S Moczko Ewa E Piletsky Sergey S

RSC advances 20140101 8

We report the development of an automated chemical reactor for solid-phase synthesis of MIP NPs in water. Operational parameters are under computer control, requiring minimal operator intervention. In this study, "ready for use" MIP NPs with sub-nanomolar affinity are prepared against pepsin A, trypsin and α-amylase in only 4 hours. ...[more]

PMID: 26722622

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