Selective Binding of Complex Glycans and Glycoproteins in Water by Molecularly Imprinted Nanoparticles.
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ABSTRACT: Synthetic receptors to recognize biological glycans are in great need for modern glycoscience and technology, but their design and synthesis have been a daunting challenge due to strong solvation of carbohydrates in water and structural complexity of the guest. Molecular imprinting in surfactant micelles with amide cross-linkers provides a convenient one-pot method to prepare nanoparticle receptors for glycosides, glycans, and glycoproteins, taking advantage of hydrogen-bonding interactions near the surfactant/water interface. Biologically competitive micromolar binding affinities were obtained in water and subtle structural differences of glycans could be distinguished.
SUBMITTER: Zangiabadi M
PROVIDER: S-EPMC7472588 | biostudies-literature |
REPOSITORIES: biostudies-literature
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