Ontology highlight
ABSTRACT:
SUBMITTER: Morciano G
PROVIDER: S-EPMC4694758 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Morciano Giampaolo G Giorgi Carlotta C Balestra Dario D Marchi Saverio S Perrone Daniela D Pinotti Mirko M Pinton Paolo P
Molecular biology of the cell 20151104 1
The B-cell lymphoma-2 (Bcl-2) family proteins are critical regulators of apoptosis and consist of both proapoptotic and antiapoptotic factors. Within this family, the myeloid cell leukemia factor 1 (Mcl-1) protein exists in two forms as the result of alternative splicing. The long variant (Mcl-1L) acts as an antiapoptotic factor, whereas the short isoform (Mcl-1S) displays proapoptotic activity. In this study, using splice-switching antisense oligonucleotides (ASOs), we increased the synthesis o ...[more]