Ontology highlight
ABSTRACT:
SUBMITTER: Chen GQ
PROVIDER: S-EPMC4695176 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Chen Guo-Qing GQ Tang Cheng-Fang CF Shi Xiao-Ke XK Lin Cheng-Yuan CY Fatima Sarwat S Pan Xiao-Hua XH Yang Da-Jian DJ Zhang Ge G Lu Ai-Ping AP Lin Shu-Hai SH Bian Zhao-Xiang ZX
Oncotarget 20150901 27
The Akt/mTORC1 pathway plays a central role in the activation of Warburg effect in cancer. Here, we present for the first time that halofuginone (HF) treatment inhibits colorectal cancer (CRC) growth both in vitro and in vivo through regulation of Akt/mTORC1 signaling pathway. Halofuginone treatment of human CRC cells inhibited cell proliferation, induced the generation of reactive oxygen species and apoptosis. As expected, reduced level of NADPH was also observed, at least in part due to inacti ...[more]