FRMD3 gene: its role in diabetic kidney disease. A narrative review.
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ABSTRACT:
SUBMITTER: Buffon MP
PROVIDER: S-EPMC4696171 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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FRMD3 gene: its role in diabetic kidney disease. A narrative review.
Buffon Marjoriê Piuco MP Sortica Denise Alves DA Gerchman Fernando F Crispim Daisy D Canani Luís Henrique LH
Diabetology & metabolic syndrome 20151230
Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus, which is considered a worldwide epidemic. Several studies have been developed in order to elucidate possible genetic factors involved in this disease. The FRMD3 gene, a strong candidate selected from genome wide association studies (GWAS), encodes the structural protein 4.1O involved in maintaining cell shape and integrity. Some single nucleotide polymorphisms (SNPs) located in FRMD3 have been associated with DKD in di ...[more]
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