Association between high expression macrophage migration inhibitory factor (MIF) alleles and West Nile virus encephalitis.
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ABSTRACT:
SUBMITTER: Das R
PROVIDER: S-EPMC4696904 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
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Association between high expression macrophage migration inhibitory factor (MIF) alleles and West Nile virus encephalitis.
Das Rituparna R Loughran Kerry K Murchison Charles C Qian Feng F Leng Lin L Song Yan Y Montgomery Ruth R RR Loeb Mark M Bucala Richard R
Cytokine 20151128
Infection with mosquito-borne West Nile virus (WNV) is usually asymptomatic but can lead to severe WNV encephalitis. The innate cytokine, macrophage migration inhibitory factor (MIF), is elevated in patients with WNV encephalitis and promotes viral neuroinvasion and mortality in animal models. In a case-control study, we examined functional polymorphisms in the MIF locus in a cohort of 454 North American patients with neuroinvasive WNV disease and found patients homozygous for high-expression MI ...[more]
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