Ontology highlight
ABSTRACT:
SUBMITTER: Hu JX
PROVIDER: S-EPMC9117661 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Hu Jin-Xia JX Ma Wei-Jing WJ He Li-Ying LY Zhang Cong-Hui CH Zhang Cheng C Wang Yan Y Chen Chao-Nan CN Shen Da-Yong DY Gao Hui-Min HM Guo Rui-Ru RR Ning Qian-Qian QQ Ye Xin-Chun XC Cui Gui-Yun GY Li Lei L
Cell death & disease 20220518 5
Ischemia-induced neuronal death leads to serious lifelong neurological deficits in ischemic stroke patients. Histone deacetylase 6 (HDAC6) is a promising target for neuroprotection in many neurological disorders, including ischemic stroke. However, the mechanism by which HDAC6 inhibition protects neurons after ischemic stroke remains unclear. Here, we discovered that genetic ablation or pharmacological inhibition of HDAC6 reduced brain injury after ischemic stroke by increasing macrophage migrat ...[more]