Ontology highlight
ABSTRACT:
SUBMITTER: Xie L
PROVIDER: S-EPMC4697171 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Xie Lili L Wartchow Charles C Shia Steven S Uehara Kyoko K Steffek Micah M Warne Robert R Sutton James J Muiru Gladys T GT Leonard Vincent H J VH Bussiere Dirksen E DE Ma Xiaolei X
The Journal of biological chemistry 20151111 1
Influenza virus polymerase catalyzes the transcription of viral mRNAs by a process known as "cap-snatching," where the 5'-cap of cellular pre-mRNA is recognized by the PB2 subunit and cleaved 10-13 nucleotides downstream of the cap by the endonuclease PA subunit. Although this mechanism is common to both influenza A (FluA) and influenza B (FluB) viruses, FluB PB2 recognizes a wider range of cap structures including m(7)GpppGm-, m(7)GpppG-, and GpppG-RNA, whereas FluA PB2 utilizes methylated G-ca ...[more]