CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer.
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ABSTRACT:
SUBMITTER: Thompson DJ
PROVIDER: S-EPMC4697192 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
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CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer.
Thompson Deborah J DJ O'Mara Tracy A TA Glubb Dylan M DM Painter Jodie N JN Cheng Timothy T Folkerd Elizabeth E Doody Deborah D Dennis Joe J Webb Penelope M PM Gorman Maggie M Martin Lynn L Hodgson Shirley S Michailidou Kyriaki K Tyrer Jonathan P JP Maranian Mel J MJ Hall Per P Czene Kamila K Darabi Hatef H Li Jingmei J Fasching Peter A PA Hein Alexander A Beckmann Matthias W MW Ekici Arif B AB Dörk Thilo T Hillemanns Peter P Dürst Matthias M Runnebaum Ingo I Zhao Hui H Depreeuw Jeroen J Schrauwen Stefanie S Amant Frederic F Goode Ellen L EL Fridley Brooke L BL Dowdy Sean C SC Winham Stacey J SJ Salvesen Helga B HB Trovik Jone J Njolstad Tormund S TS Werner Henrica M J HM Ashton Katie K Proietto Tony T Otton Geoffrey G Carvajal-Carmona Luis L Tham Emma E Liu Tao T Mints Miriam M Scott Rodney J RJ McEvoy Mark M Attia John J Holliday Elizabeth G EG Montgomery Grant W GW Martin Nicholas G NG Nyholt Dale R DR Henders Anjali K AK Hopper John L JL Traficante Nadia N Ruebner Matthias M Swerdlow Anthony J AJ Burwinkel Barbara B Brenner Hermann H Meindl Alfons A Brauch Hiltrud H Lindblom Annika A Lambrechts Diether D Chang-Claude Jenny J Couch Fergus J FJ Giles Graham G GG Kristensen Vessela N VN Cox Angela A Bolla Manjeet K MK Wang Qin Q Bojesen Stig E SE Shah Mitul M Luben Robert R Khaw Kay-Tee KT Pharoah Paul D P PD Dunning Alison M AM Tomlinson Ian I Dowsett Mitch M Easton Douglas F DF Spurdle Amanda B AB
Endocrine-related cancer 20151116 2
Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancer and with estradiol (E2) concentrations. We analyzed 2937 single nucleotide polymorphisms (SNPs) in 6608 endometrial cancer cases and 37 925 controls and report the first genome wide-significant association between endometrial cancer and a CYP19A1 SNP (rs727479 in intron 2, P=4.8×10(-11)). SNP rs727479 was also among those most strongly associated with circulating E2 concentrations in 2767 post-menopaus ...[more]
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