Ontology highlight
ABSTRACT:
SUBMITTER: Ding N
PROVIDER: S-EPMC4697417 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Ding Ning N Hah Nasun N Yu Ruth T RT Sherman Mara H MH Benner Chris C Leblanc Mathias M He Mingxiao M Liddle Christopher C Downes Michael M Evans Ronald M RM
Proceedings of the National Academy of Sciences of the United States of America 20151207 51
Liver fibrosis is characterized by the persistent deposition of extracellular matrix components by hepatic stellate cell (HSC)-derived myofibroblasts. It is the histological manifestation of progressive, but reversible wound-healing processes. An unabated fibrotic response results in chronic liver disease and cirrhosis, a pathological precursor of hepatocellular carcinoma. We report here that JQ1, a small molecule inhibitor of bromodomain-containing protein 4 (BRD4), a member of bromodomain and ...[more]