Ontology highlight
ABSTRACT:
SUBMITTER: Yao J
PROVIDER: S-EPMC4697872 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Yao Junjie J Kaberniuk Andrii A AA Li Lei L Shcherbakova Daria M DM Zhang Ruiying R Wang Lidai L Li Guo G Verkhusha Vladislav V VV Wang Lihong V LV
Nature methods 20151109 1
Photoacoustic tomography (PAT) of genetically encoded probes allows for imaging of targeted biological processes deep in tissues with high spatial resolution; however, high background signals from blood can limit the achievable detection sensitivity. Here we describe a reversibly switchable nonfluorescent bacterial phytochrome for use in multiscale photoacoustic imaging, BphP1, with the most red-shifted absorption among genetically encoded probes. BphP1 binds a heme-derived biliverdin chromophor ...[more]