Ontology highlight
ABSTRACT:
SUBMITTER: Lindsey JW
PROVIDER: S-EPMC4698215 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Lindsey J William JW deGannes Samantha L SL Pate Kimberly A KA Zhao Xiurong X
Molecular immunology 20151128
Epstein-Barr virus (EBV) is associated with multiple sclerosis (MS), and antibodies to the EBV nuclear antigen-1 (EBNA-1) are consistently increased in MS patients. The hypothesis of this study is that anti-EBNA-1 antibodies cross-react with a self antigen in MS patients. We affinity purified anti-EBNA-1 antibodies from human plasma, used the anti-EBNA-1 to immunoprecipitate antigens from human brain, and identified bound antigens with mass spectrometry. Anti-EBNA-1 consistently bound heterogene ...[more]