Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC4698351 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20150820 43
Azido (18) F-arenes are important and versatile building blocks for the radiolabeling of biomolecules via Huisgen cycloaddition ("click chemistry") for positron emission tomography (PET). However, routine access to such clickable agents is challenged by inefficient and/or poorly defined multistep radiochemical approaches. A high-yielding direct radiofluorination for azido (18) F-arenes was achieved through the development of an ortho-oxygen-stabilized iodonium derivative (OID). This OID strategy ...[more]